ParkinsonCanadaV1, Main, Exploration, bibRecord, 001626

Neuroimaging in Parkinson’s Disease

Identifieur interne : 001626 ( Main/Exploration ); précédent : 001625; suivant : 001627

Neuroimaging in Parkinson’s Disease

Auteurs : A. Jon Stoessl

Source :

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics [ 1933-7213 ] ; 2011.

RBID : PMC:3075732

English descriptors

KwdEn :
- Dopamine (metabolism), Humans, Magnetic Resonance Imaging, Parkinson Disease (diagnosis), Parkinson Disease (metabolism), Positron-Emission Tomography, Tomography, Emission-Computed, Single-Photon.
MESH :
- chemical , metabolism : Dopamine.
- diagnosis : Parkinson Disease.
- metabolism : Parkinson Disease.
- Humans, Magnetic Resonance Imaging, Positron-Emission Tomography, Tomography, Emission-Computed, Single-Photon.

Abstract

Summary

Parkinson’s disease (PD) is a common disorder in which the primary features can be related to dopamine deficiency. Changes on structural imaging are limited, but a wealth of abnormalities can be detected using positron emission tomography, single photon emission computed tomography, or functional magnetic resonance imaging to detect changes in neurochemical pathology or functional connectivity. The changes detected on these studies may reflect the disease process itself and/or compensatory responses to the disease, or they may arise in association with disease- and/or treatment-related complications. This review will focus mainly on neurochemical and metabolic studies and reviews various approaches to the assessment of dopaminergic function as well as the function of other neurotransmitters that may be affected in PD. A number of clinical applications are highlighted, including diagnostic utility, identification of preclinical disease, changes associated with motor and nonmotor complications of PD, and the effects of various therapeutic interventions.

Electronic supplementary material

The online version of this article (doi:10.1007/s13311-010-0007-z) contains supplementary material, which is available to authorized users.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075732

DOI: 10.1007/s13311-010-0007-z
PubMed: 21274687
PubMed Central: 3075732

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><title>Summary</title>
<p>Parkinson’s disease (PD) is a common disorder in which the primary features can be related to dopamine deficiency. Changes on structural imaging are limited, but a wealth of abnormalities can be detected using positron emission tomography, single photon emission computed tomography, or functional magnetic resonance imaging to detect changes in neurochemical pathology or functional connectivity. The changes detected on these studies may reflect the disease process itself and/or compensatory responses to the disease, or they may arise in association with disease- and/or treatment-related complications. This review will focus mainly on neurochemical and metabolic studies and reviews various approaches to the assessment of dopaminergic function as well as the function of other neurotransmitters that may be affected in PD. A number of clinical applications are highlighted, including diagnostic utility, identification of preclinical disease, changes associated with motor and nonmotor complications of PD, and the effects of various therapeutic interventions.</p>
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La maladie de Parkinson au Canada (serveur d'exploration)

Neuroimaging in Parkinson’s Disease

Neuroimaging in Parkinson’s Disease

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
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